Although other cell penetrating peptides can be internalized by many cell types, the diverse central nervous system cell types examined here had limited capacity to internalize NFLTBS.4063 and were unaffected by in vitro peptide exposure. In contrast, a markedly enhanced ability to internalize the peptide was a prominent feature shared among multiple glioma cell lines, and such internalization was accompanied by major disruptions in their microtubule networks, reduced motility, inhibition of proliferation and apoptosis. Based on these observations, we explored the possibility that infusion of the peptide into gliomas generated in a transplant model would have therapeutic benefit.Cruz, who signed a multiyear, $43 million contract before the start of training camp, went to the locker room early in the first quarter. The team did not say which one and it was not clear when he was hurt although he was knocked to the turf on a long pass on the third play from scrimmage. Pass interferenc