But the pick will impact his career forever.For years, people will start a conversation with, "You remember when Rivera was a rookie head coach in 2011 and with the No.1 pick the Panthers . " Fill in the rest of that sentence, and you will fill in a huge paragraph in Rivera's career.Coaches often can't survive a misfire at No.1, particularly at quarterback and even if they don't make the final call. Oakland coach Lane Kiffin didn't want JaMarcus Russell for the No.1 pick in 2007, got overruled by owner Al Davis and had to coach him anyway.To determine if the toxic effect of the peptide is mediated through an apoptotic mechanism, as observed for other microtubulebinding drugs, F98, 9L glioma cells and astrocytes were incubated for 72 hours with 100 of the peptide or vehicle alone, stained with propidium iodide (PI) and labeled for annexin V. Viable cells with intact membranes exclude PI, while in cells undergoing apoptosis, phospholipid phosphatidylserine (PS) translocates